Genetics of Parkinson disease: paradigm shifts and future prospects
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg1831.pdf
Reference140 articles.
1. Tanner, C. M. Is the cause of Parkinson's disease environmental or hereditary? Evidence from twin studies. Adv. Neurol. 91, 133–142 (2003).
2. Wirdefeldt, K., Gatz, M., Schalling, M. & Pedersen, N. L. No evidence for heritability of Parkinson disease in Swedish twins. Neurology 63, 305–311 (2004).
3. Zimprich, A. et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44, 601–607 (2004). Describes the identification of the PARK8 gene, LRRK2 , as a cause of late-onset Parkinson disease that might be associated with a pleomorphic pathology.
4. Valente, E. M. et al. Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 304, 1158–1160 (2004).
5. Singleton, A. B. et al. α-Synuclein locus triplication causes Parkinson's disease. Science 302, 841 (2003). Describes the discovery of α-synuclein multiplication mutations, which showed that simple overexpression of the wild-type protein is sufficient to cause disease. This work also suggests that Parkinson disease and dementia with Lewy bodies share the same aetiology.
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