Targeting the murine serotonin transporter: insights into human neurobiology
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Neuroscience
Link
http://www.nature.com/articles/nrn2284.pdf
Reference131 articles.
1. Lesch, K.-P. et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274, 1527–1531 (1996). This paper provided the first demonstration that a functional-repeat length variation in the transcriptional control region of the SLC6A4 gene is associated with anxiety-, depression-, and aggression-related personality traits. The authors also suggest a hypothesis for the SERT-specific genetic susceptibility of affective illnesses and related disorders.
2. Hu, X. Z. et al. Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am. J. Hum. Genet. 78, 815–826 (2006).
3. Lesch, K. P. & Murphy, D. L. in Membrane Transport Diseases: Molecular Basis of Inherited Transport Defects (eds Broer, S. & Wagner, C. A.) 349–364 (Kluwer Academic/Plenum, New York, 2003).
4. Murphy, D. L., Lerner, A., Rudnick, G. & Lesch, K. P. Serotonin transporter: gene, genetic disorders, and pharmacogenetics. Mol. Interv. 4, 109–123 (2004).
5. Greenberg, B. D. et al. Association between the serotonin transporter promoter polymorphism and personality traits in a primarily female population sample. Am. J. Med. Genet. 96, 202–216 (2000).
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