SARS-CoV-2 Omicron variant virus isolates are highly sensitive to interferon treatment
Author:
Funder
Frankfurter Stiftung fuer krebskranke Kinder
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Genetics,Molecular Biology,Biochemistry
Link
https://www.nature.com/articles/s41421-022-00408-z.pdf
Reference15 articles.
1. Davies, M.-A. et al. Outcomes of laboratory-confirmed SARS-CoV-2 infection in the Omicron-driven fourth wave compared with previous waves in the Western Cape Province, South Africa. medRxiv https://www.medrxiv.org/content/10.1101/2022.01.12.22269148v1 (2022).
2. Kozlov, M. Omicron’s feeble attack on the lungs could make it less dangerous. Nature 601, 177 (2022).
3. Bojkova, D. et al. Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant SARS-CoV-2 isolates. Cell Res. 32, 319–321 (2022).
4. Yin, X. et al. MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells. Cell Rep. 34, 108628 (2021).
5. Wong, L. R. & Perlman, S. Immune dysregulation and immunopathology induced by SARS-CoV-2 and related coronaviruses - are we our own worst enemy? Nat. Rev. Immunol. 22, 47–56 (2022).
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