Abstract
AbstractHeparan sulfate proteoglycans (HSPGs) are part of proteoglycan family. They are composed of heparan sulfate (HS)-type glycosaminoglycan (GAG) chains covalently linked to a core protein. By interacting with growth factors and/or receptors, they regulate numerous pathways including Wnt, hedgehog (Hh), bone morphogenic protein (BMP) and fibroblast growth factor (FGF) pathways. They act as inhibitor or activator of these pathways to modulate embryonic and adult stem cell fate during organ morphogenesis, regeneration and homeostasis. This review summarizes the knowledge on HSPG structure and classification and explores several signaling pathways regulated by HSPGs in stem cell fate. A specific focus on hair follicle stem cell fate and the possibility to target HSPGs in order to tackle hair loss are discussed in more dermatological and cosmeceutical perspectives.
Funder
This study was made in collaboration with BASF Beauty Care Solutions. Ms Charlie Colin-Pierre is a BASF /CNRS funded PhD fellow.
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Developmental Biology,Biomedical Engineering,Medicine (miscellaneous)
Reference252 articles.
1. Bernard, B. A. La vie révélée du follicule de cheveu humain. Méd. Sci. 22, 138–143 (2006).
2. Geras, A. J. Dermatology: A Medical Artist’s Interpretation (Sandoz Medical Publications, Sandoz Pharma Limited, 1990).
3. Sada, A. & Tumbar, T. New insights into mechanisms of stem cell daughter fate determination in regenerative tissues. Int. Rev. Cell Mol. Biol. 300, 1–50 (2013).
4. Stenn, K. Exogen is an active, separately controlled phase of the hair growth cycle. J. Am. Acad. Dermatol. 52, 374–375 (2005).
5. Milner, Y. et al. Exogen, shedding phase of the hair growth cycle: characterization of a mouse model. J. Invest. Dermatol. 119, 639–644 (2002).
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