“Cruising together”—ASC specks and SAA, a perfect match in chronic inflammation
Author:
Funder
EC | ERC | HORIZON EUROPE European Research Council
EC | HORIZON EUROPE Framework Programme
Deutsche Forschungsgemeinschaft
Publisher
Springer Science and Business Media LLC
Link
https://www.embopress.org/doi/epdf/10.1038/s44321-024-00109-y
Reference11 articles.
1. Balci-Peynircioglu B, Waite AL, Schaner P, Taskiran ZE, Richards N, Orhan D, Gucer S, Ozen S, Gumucio D, Yilmaz E (2008) Expression of ASC in renal tissues of familial Mediterranean fever patients with amyloidosis: postulating a role for ASC in AA type amyloid deposition. Exp Biol Med 233:1324–1333
2. Baroja-Mazo A, Martín-Sánchez F, Gomez AI, Martínez CM, Amores-Iniesta J, Compan V, Barberà-Cremades M, Yagüe J, Ruiz-Ortiz E, Antón J et al (2014) The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat Immunol 15:738–748
3. Basiorka AA, McGraw KL, Abbas-Aghababazadeh F, McLemore AF, Vincelette ND, Ward GA, Eksioglu EA, Sallman DA, Ali NA, Padron E et al (2018) Assessment of ASC specks as a putative biomarker of pyroptosis in myelodysplastic syndromes: an observational cohort study. Lancet Haematol 5:e393–e402
4. Bertheloot D, Wanderley CW, Schneider AH, Schiffelers LD, Wuerth JD, Todtmann JM, Maasewerd S, Hawwari I, Duthie F, Rohland C et al (2022) Nanobodies dismantle post-pyroptotic ASC specks and counteract inflammation in vivo. EMBO Mol Med 14:e15415
5. Coll RC, Schroder K, Pelegrin P (2022) NLRP3 and pyroptosis blockers for treating inflammatory diseases. Trends Pharm Sci 43:653–668
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