Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity
Author:
Funder
U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke
U.S. Department of Health & Human Services | NIH | National Cancer Institute
Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41467-024-51181-4.pdf
Reference64 articles.
1. Coste, B. et al. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 330, 55–60 (2010).
2. Szczot, M., Nickolls, A. R., Lam, R. M. & Chesler, A. T. The form and function of PIEZO2. Annu. Rev. Biochem 90, 507–534 (2021).
3. Murthy, S. E., Dubin, A. E. & Patapoutian, A. Piezos thrive under pressure: mechanically activated ion channels in health and disease. Nat. Rev. Mol. Cell Biol. 18, 771–783 (2017).
4. Xiao, B. Levering mechanically activated piezo channels for potential pharmacological intervention. Annu Rev. Pharm. Toxicol. 60, 195–218 (2020).
5. Syeda, R. et al. Chemical activation of the mechanotransduction channel Piezo1. Elife 4, e07369 (2015).
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