Integration of molecular profiles in a longitudinal wellness profiling cohort-Reference-Cited by-同舟云学术

Integration of molecular profiles in a longitudinal wellness profiling cohort

Published:2020-09-08 Issue:1 Volume:11 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Tebani Abdellah,Gummesson Anders^ORCID,Zhong Wen^ORCID,Koistinen Ina Schuppe,Lakshmikanth Tadepally^ORCID,Olsson Lisa M.^ORCID,Boulund Fredrik^ORCID,Neiman Maja,Stenlund Hans,Hellström Cecilia^ORCID,Karlsson Max J.^ORCID,Arif Muhammad^ORCID,Dodig-Crnković Tea^ORCID,Mardinoglu Adil^ORCID,Lee Sunjae,Zhang Cheng^ORCID,Chen Yang,Olin Axel^ORCID,Mikes Jaromir^ORCID,Danielsson Hanna^ORCID,von Feilitzen Kalle,Jansson Per-Anders,Angerås Oskar,Huss Mikael,Kjellqvist Sanela,Odeberg Jacob^ORCID,Edfors Fredrik^ORCID,Tremaroli Valentina,Forsström Björn,Schwenk Jochen M.^ORCID,Nilsson Peter,Moritz Thomas,Bäckhed Fredrik^ORCID,Engstrand Lars,Brodin Petter,Bergström Göran^ORCID,Uhlen Mathias^ORCID,Fagerberg Linn^ORCID

Abstract

AbstractAn important aspect of precision medicine is to probe the stability in molecular profiles among healthy individuals over time. Here, we sample a longitudinal wellness cohort with 100 healthy individuals and analyze blood molecular profiles including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies and immune cell profiling, complemented with gut microbiota composition and routine clinical chemistry. Overall, our results show high variation between individuals across different molecular readouts, while the intra-individual baseline variation is low. The analyses show that each individual has a unique and stable plasma protein profile throughout the study period and that many individuals also show distinct profiles with regards to the other omics datasets, with strong underlying connections between the blood proteome and the clinical chemistry parameters. In conclusion, the results support an individual-based definition of health and show that comprehensive omics profiling in a longitudinal manner is a path forward for precision medicine.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

https://www.nature.com/articles/s41467-020-18148-7.pdf

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