Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases-Reference-Cited by-同舟云学术

Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases

Published:2018-10-19 Issue:1 Volume:9 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Andersen Jacob Lauwring,Gesser Borbala,Funder Erik Daa,Nielsen Christine Juul Fælled,Gotfred-Rasmussen Helle,Rasmussen Mads Kirchheiner,Toth Rachel,Gothelf Kurt Vesterager^ORCID,Arthur J. Simon C.,Iversen Lars,Nissen Poul^ORCID

Funder

Lundbeckfonden

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry

Link

http://www.nature.com/articles/s41467-018-06787-w.pdf

Reference32 articles.

1. Mrowietz, U. et al. Efficacy and safety of LAS41008 (dimethyl fumarate) in adults with moderate-to-severe chronic plaque psoriasis: a randomized, double-blind, Fumaderm(R) - and placebo-controlled trial (BRIDGE). Br. J. Dermatol. 176, 615–623 (2017).

2. Blair, H. A. Dimethyl fumarate: a review in moderate to severe plaque psoriasis. Drugs 78, 123–130 (2018).

3. Gold, R. et al. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N. Engl. J. Med. 367, 1098–1107 (2012).

4. Schmidt, T. J., Ak, M. & Mrowietz, U. Reactivity of dimethyl fumarate and methylhydrogen fumarate towards glutathione and N-acetyl-L-cysteine-preparation of S-substituted thiosuccinic acid esters. Bioorg. Med. Chem. 15, 333–342 (2007).

5. Rostami-Yazdi, M., Clement, B., Schmidt, T. J., Schinor, D. & Mrowietz, U. Detection of metabolites of fumaric acid esters in human urine: implications for their mode of action. J. Invest. Dermatol. 129, 231–234 (2009).

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