Donkey genomes provide new insights into domestication and selection for coat color
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Published:2020-12
Issue:1
Volume:11
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Wang ChangfaORCID, Li HaijingORCID, Guo Yu, Huang JinmingORCID, Sun YanORCID, Min Jiumeng, Wang JinpengORCID, Fang Xiaodong, Zhao Zicheng, Wang Shuai, Zhang Yanlin, Liu Qingfeng, Jiang Qiang, Wang Xiuge, Guo Yijun, Yang Chunhong, Wang Yinchao, Tian Fang, Zhuang Guilong, Fan Yanna, Gao Qican, Li Yuhua, Ju Zhihua, Li Jianbin, Li Rongling, Hou Minghai, Yang Guiwen, Liu Guiqin, Liu Wenqiang, Guo Jiao, Pan Shanshan, Fan Guangyi, Zhang Wei, Zhang Ruitao, Yu Jie, Zhang Xinhao, Yin Qi, Ji Chuanliang, Jin Yuanchun, Yue Guidong, Liu Mei, Xu JiakeORCID, Liu Shimin, Jordana JordiORCID, Noce AntoniaORCID, Amills MarcelORCID, Wu Dong DongORCID, Li ShuaichengORCID, Zhou Xiangshan, Zhong JifengORCID
Abstract
AbstractCurrent knowledge about the evolutionary history of donkeys is still incomplete due to the lack of archeological and whole-genome diversity data. To fill this gap, we have de novo assembled a chromosome-level reference genome of one male Dezhou donkey and analyzed the genomes of 126 domestic donkeys and seven wild asses. Population genomics analyses indicate that donkeys were domesticated in Africa and conclusively show reduced levels of Y chromosome variability and discordant paternal and maternal histories, possibly reflecting the consequences of reproductive management. We also investigate the genetic basis of coat color. While wild asses show diluted gray pigmentation (Dun phenotype), domestic donkeys display non-diluted black or chestnut coat colors (non-Dun) that were probably established during domestication. Here, we show that the non-Dun phenotype is caused by a 1 bp deletion downstream of the TBX3 gene, which decreases the expression of this gene and its inhibitory effect on pigment deposition.
Funder
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Reference99 articles.
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