Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection-Reference-Cited by-同舟云学术

Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection

Published:2022-02-23 Issue:1 Volume:13 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Pekayvaz Kami^ORCID,Leunig Alexander^ORCID,Kaiser Rainer^ORCID,Joppich Markus^ORCID,Brambs Sophia,Janjic Aleksandar^ORCID,Popp Oliver,Nixdorf Daniel^ORCID,Fumagalli Valeria,Schmidt Nora^ORCID,Polewka Vivien,Anjum Afra^ORCID,Knottenberg Viktoria,Eivers Luke,Wange Lucas E.^ORCID,Gold Christoph,Kirchner Marieluise^ORCID,Muenchhoff Maximilian^ORCID,Hellmuth Johannes C.^ORCID,Scherer Clemens^ORCID,Rubio-Acero Raquel,Eser Tabea,Deák Flora,Puchinger Kerstin,Kuhl Niklas,Linder Andreas,Saar Kathrin^ORCID,Tomas Lukas^ORCID,Schulz Christian^ORCID,Wieser Andreas,Enard Wolfgang,Kroidl Inge,Geldmacher Christof,von Bergwelt-Baildon Michael,Keppler Oliver T.,Munschauer Mathias^ORCID,Iannacone Matteo^ORCID,Zimmer Ralf,Mertins Philipp^ORCID,Hubner Norbert,Hoelscher Michael,Massberg Steffen^ORCID,Stark Konstantin^ORCID,Nicolai Leo^ORCID

Abstract

AbstractThe antiviral immune response to SARS-CoV-2 infection can limit viral spread and prevent development of pneumonic COVID-19. However, the protective immunological response associated with successful viral containment in the upper airways remains unclear. Here, we combine a multi-omics approach with longitudinal sampling to reveal temporally resolved protective immune signatures in non-pneumonic and ambulatory SARS-CoV-2 infected patients and associate specific immune trajectories with upper airway viral containment. We see a distinct systemic rather than local immune state associated with viral containment, characterized by interferon stimulated gene (ISG) upregulation across circulating immune cell subsets in non-pneumonic SARS-CoV2 infection. We report reduced cytotoxic potential of Natural Killer (NK) and T cells, and an immune-modulatory monocyte phenotype associated with protective immunity in COVID-19. Together, we show protective immune trajectories in SARS-CoV2 infection, which have important implications for patient prognosis and the development of immunomodulatory therapies.

Publisher

Springer Science and Business Media LLC

Subject

General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary

Link

https://www.nature.com/articles/s41467-022-28508-0.pdf

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