Stereoselective synthesis of sulfur-containing β-enaminonitrile derivatives through electrochemical Csp3–H bond oxidative functionalization of acetonitrile
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry
Link
http://www.nature.com/articles/s41467-019-08762-5.pdf
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2. Fleming, F. F., Yao, L., Ravikumar, P. C., Funk, L. & Shook, B. C. Nitrile-containing pharmaceuticals: efficacious roles of the nitrile pharmacophore. J. Med. Chem. 53, 7902–7917 (2010).
3. Fleming, F. Nitrile-containing natural products. Nat. Prod. Rep. 16, 597–606 (1999).
4. Rappoport, Z. The Chemistry of the Cyano Group (Wiley, London, 1970).
5. Culkin, D. A. & Hartwig, J. F. Palladium-catalyzed α-arylation of carbonyl compounds and nitriles. Acc. Chem. Res. 36, 234–245 (2003).
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