The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo-Reference-Cited by-同舟云学术

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The small molecule inhibitor of SARS-CoV-2 3CLpro EDP-235 prevents viral replication and transmission in vivo

Published:2024-08-01 Issue:1 Volume:15 Page:
ISSN:2041-1723
Container-title:Nature Communications
language:en
Short-container-title:Nat Commun

Author:

Rhodin Michael H. J.^ORCID,Reyes Archie C.,Balakrishnan Anand^ORCID,Bisht Nalini,Kelly Nicole M.,Gibbons Joyce Sweeney,Lloyd Jonathan,Vaine Michael,Cressey Tessa,Crepeau Miranda,Shen Ruichao,Manalo Nathan,Castillo Jonathan,Levene Rachel E.,Leonard Daniel,Zang Tianzhu,Jiang Lijuan,Daniels Kellye,Cox Robert M.^ORCID,Lieber Carolin M.,Wolf Josef D.^ORCID,Plemper Richard K.^ORCID,Leist Sarah R.^ORCID,Scobey Trevor,Baric Ralph S.^ORCID,Wang Guoqiang,Goodwin Bryan,Or Yat Sun

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41467-024-50931-8.pdf

Reference71 articles.

1. World Health Organization. Coronavirus disease (COVID-19). (2023).

2. Li, G., Hilgenfeld, R., Whitley, R. & De Clercq, E. Therapeutic strategies for COVID-19: progress and lessons learned. Nat. Rev. Drug Discov. 22, 449–475 (2023).

3. Hammond, J. et al. Oral Nirmatrelvir for High-Risk, Nonhospitalized Adults with Covid-19. N. Engl. J. Med. 386, 1397–1408 (2022).

4. Jayk Bernal, A. et al. Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients. N. Engl. J. Med. 386, 509–520 (2022).

5. Matrajt, L., Brown, E. R., Cohen, M. S., Dimitrov, D. & Janes, H. Could widespread use of antiviral treatment curb the COVID-19 pandemic? A modeling study. BMC Infect. Dis. 22, 683 (2022).

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