Abstract
AbstractIn Aotearoa New Zealand, zoster vaccine live is used for the prevention of zoster and associated complications in adults. This study assessed the risk of pre-specified serious adverse events following zoster vaccine live immunisation among adults in routine clinical practice. We conducted a self-controlled case series study using routinely collected national data. We compared the incidence of serious adverse events during the at-risk period with the control period. Rate ratios were estimated using Conditional Poisson regression models. Falsification outcomes analyses were used to evaluate biases in our study population. From April 2018 to July 2021, 278,375 received the vaccine. The rate ratio of serious adverse events following immunisation was 0·43 (95% confidence interval [CI]: 0·37–0·50). There was no significant increase in the risk of cerebrovascular accidents, acute myocardial infarction, acute pericarditis, acute myocarditis, and Ramsay–Hunt Syndrome. The herpes zoster vaccine is safe in adults in Aotearoa New Zealand.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary
Reference47 articles.
1. Gershon A. A., Marin M. & Seward J. F. Varicella Vaccines. in (eds Plotkin S. A., Orenstein W. A., Offit P. A., Edwards K. M.). Plotkin’s Vaccines. 7th ed. (Elsevier; 2018). p. 1145–1180.e17.
2. Levin M. J. Zoster Vaccines. in (eds Stanley Plotkin, Walter Orenstein, Paul Offit, Kathryn M. Edwards). Plotkin’s Vaccines. 7th ed. 19103-2899: (Elsevier, Philadelphia, PA, 2018). p. 1268–1281.
3. Ministry of Health. Immunisation Handbook 2020 New Zealand: Ministry of Health. https://www.health.govt.nz/our-work/immunisation-handbook-2020/23-zoster-herpes-zoster-shingles (2022).
4. Oxman, M. N. et al. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N. Engl. J. Med. 352, 2271–2284 (2005).
5. Tricco, A. C. et al. Efficacy, effectiveness, and safety of herpes zoster vaccines in adults aged 50 and older: systematic review and network meta-analysis. Br. Med. J. 363, k4029 (2018).
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献