A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate-Reference-Cited by-同舟云学术

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Published:2016-04-25 Issue:6 Volume:12 Page:452-458
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Pacold Michael E^ORCID,Brimacombe Kyle R,Chan Sze Ham,Rohde Jason M,Lewis Caroline A,Swier Lotteke J Y M,Possemato Richard,Chen Walter W,Sullivan Lucas B,Fiske Brian P,Cho Steve,Freinkman Elizaveta,Birsoy Kıvanç,Abu-Remaileh Monther,Shaul Yoav D,Liu Chieh Min,Zhou Minerva,Koh Min Jung,Chung Haeyoon,Davidson Shawn M,Luengo Alba,Wang Amy Q,Xu Xin,Yasgar Adam,Liu Li,Rai Ganesha,Westover Kenneth D,Vander Heiden Matthew G,Shen Min,Gray Nathanael S^ORCID,Boxer Matthew B,Sabatini David M

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.2070.pdf

Reference36 articles.

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3. Farber, S., Diamond, L.K., Mercer, R., Sylvester, R. & Wolff, J. Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid. N. Engl. J. Med. 238, 787–793 (1948).

4. Vander Heiden, M.G. Targeting cancer metabolism: a therapeutic window opens. Nat. Rev. Drug Discov. 10, 671–684 (2011).

5. Cantor, J.R. & Sabatini, D.M. Cancer cell metabolism: one hallmark, many faces. Cancer Discov. 2, 881–898 (2012).

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