The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors-Reference-Cited by-同舟云学术

The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

Published:2010-01-10 Issue:2 Volume:6 Page:117-124
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Berndt Alex,Miller Simon,Williams Olusegun,Le Daniel D,Houseman Benjamin T,Pacold Joseph I,Gorrec Fabrice,Hon Wai-Ching,Ren Pingda,Liu Yi,Rommel Christian,Gaillard Pascale,Rückle Thomas,Schwarz Matthias K,Shokat Kevan M,Shaw Jeffrey P,Williams Roger L

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.293.pdf

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4. Sundstrom, T.J., Anderson, A.C. & Wright, D.L. Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity. Org. Biomol. Chem. 7, 840–850 (2009).

5. Miled, N. et al. Mechanism of two classes of cancer mutations in the phosphoinositide 3-kinase catalytic subunit. Science 317, 239–242 (2007).

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