Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery-Reference-Cited by-同舟云学术

Allosteric non-bisphosphonate FPPS inhibitors identified by fragment-based discovery

Published:2010-08-15 Issue:9 Volume:6 Page:660-666
ISSN:1552-4450
Container-title:Nature Chemical Biology
language:en
Short-container-title:Nat Chem Biol

Author:

Jahnke Wolfgang,Rondeau Jean-Michel,Cotesta Simona,Marzinzik Andreas,Pellé Xavier,Geiser Martin,Strauss André,Götte Marjo,Bitsch Francis,Hemmig René,Henry Chrystèle,Lehmann Sylvie,Glickman J Fraser,Roddy Thomas P,Stout Steven J,Green Jonathan R

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Molecular Biology

Link

http://www.nature.com/articles/nchembio.421.pdf

Reference35 articles.

1. Rogers, M.J. New insights into the molecular mechanisms of action of bisphosphonates. Curr. Pharm. Des. 9, 2643–2658 (2003).

2. Stresing, V., Daubine, F., Benzaid, I., Monkkonen, H. & Clezardin, P. Bisphosphonates in cancer therapy. Cancer Lett. 257, 16–35 (2007).

3. Gnant, M. et al. Endocrine therapy plus zoledronic acid in premenopausal breast cancer. N. Engl. J. Med. 360, 679–691 (2009).

4. Poynter, J.N. et al. Statins and the risk of colorectal cancer. N. Engl. J. Med. 352, 2184–2192 (2005).

5. Fournier, P.G. et al. Lowering bone mineral affinity of bisphosphonates as a therapeutic strategy to optimize skeletal tumor growth inhibition in vivo. Cancer Res. 68, 8945–8953 (2008).

Cited by 117 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Farnesyl pyrophosphate synthase inhibitors with antiosteoporosis efficacy in ovariectomized rats: A mixed binding approach beyond bisphosphonates;European Journal of Medicinal Chemistry;2024-10

2. Hit me with your best shot: Integrated hit discovery for the next generation of drug targets;Drug Discovery Today;2024-10

3. Peptides as modulators of FPPS enzyme: a multifaceted evaluation from the design to the mechanism of action;European Journal of Medicinal Chemistry;2024-09

4. Inhibition of human mevalonate kinase by allosteric inhibitors of farnesyl pyrophosphate synthase;FEBS Open Bio;2024-06-23

5. Discovery and Evaluation of C6-Substituted Pyrazolopyrimidine-Based Bisphosphonate Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase and Evaluation of Their Antitumor Efficacy in Multiple Myeloma, Pancreatic Ductal Adenocarcinoma, and Colorectal Cancer;Journal of Medicinal Chemistry;2023-11-20