The inositol 5-phosphatase SHIP is expressed as 145 and 135 kDa proteins in blood and bone marrow cells in vivo, whereas carboxyl-truncated forms of SHIP are generated by proteolytic cleavage in vitro-Reference-Cited by-同舟云学术

The inositol 5-phosphatase SHIP is expressed as 145 and 135 kDa proteins in blood and bone marrow cells in vivo, whereas carboxyl-truncated forms of SHIP are generated by proteolytic cleavage in vitro

Published:2001-01 Issue:1 Volume:15 Page:112-120
ISSN:0887-6924
Container-title:Leukemia
language:en
Short-container-title:Leukemia

Author:

Horn S,Meyer J,Heukeshoven J,Fehse B,Schulze C,Li S,Frey J,Poll S,Stocking C,Jücker M

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Link

http://www.nature.com/articles/2401990.pdf

Reference33 articles.

1. Liu L, Damen JE, Cutler RL, Krystal G . Multiple Cytokines stimulate the binding of a common 145-kilodalton protein to Shc at the Grb2 recognition site of Shc Mol Cell Biol 1994 14: 6926–6935

2. Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G . The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase Proc Natl Acad Sci USA 1996 93: 1689–1693

3. Kavanaugh WM, Pot DA, Chin SM, Deuter-Reinhard M, Jefferson AB, Norris FA, Masiarz FR, Cousens LS, Majerus PW, Williams LT . Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2 Curr Biol 1996 6: 438–445

4. Lioubin MN, Algate PA, Schickwann Tsai, Carlberg K, Aebersold R, Rohrschneider LR . p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity Genes Dev 1996 10: 1084–1095

5. Helgason CD, Damen JE, Rosten P, Grewal R, Sorenson P, Chappel SM, Borowski A, Jirik F, Krystal G, Humphries RK . Targeted disruption of SHIP leads to hematopoietic perturbations, lung pathology, and a shortened life span Genes Dev 1998 12: 1610–1620

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