A distinctive nuclear morphology in acute myeloid leukemia is strongly associated with loss of HLA-DR expression and FLT3 internal tandem duplication

Author:

Kussick S J,Stirewalt D L,Yi H S,Sheets K M,Pogosova-Agadjanyan E,Braswell S,Norwood T H,Radich J P,Wood B L

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Reference26 articles.

1. Jaffe ES, Harris NL, Stein H, Vardiman JW . WHO Classification of Tumours: Pathology and Genetics of Tumours of the Haematopoietic and Lymphoid Tissues. IARC Press: Lyon, 2001.

2. Gilliland DG, Griffin JD . The roles of FLT3 in hematopoiesis and leukemia. Blood 2002; 100: 1532–1542.

3. Stirewalt DL, Radich JP . The role of FLT3 in haematopoietic malignancies. NatRev Cancer 2003; 3: 650–665.

4. Nakao M, Yokota S, Iwai T, Kaneko H, Horiike S, Kashima K et al. Internal tandem duplication of the Flt3 gene found in acute myeloid leukemia. Leukemia 1996; 10: 1911–1918.

5. Kiyoi H, Towatari M, Yokota S, Hamaguchi M, Ohno R, Saito H et al. Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product. Leukemia 1998; 12: 1333–1337.

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