In vitro cytotoxicity of aplidin and crossresistance with other cytotoxic drugs in childhood leukemic and normal bone marrow and blood samples: a rational basis for clinical development

Author:

Bresters D,Broekhuizen A J F,Kaaijk P,Faircloth G T,Jimeno J,Kaspers G J L

Publisher

Springer Science and Business Media LLC

Subject

Oncology,Cancer Research,Hematology

Reference30 articles.

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2. Depenbrock H, Peter R, Faircloth GT, Manzanares I, Jimeno J, Hanauske AR . In vitro activity of aplidine, a new marine-derived anti-cancer compound, on freshly explanted clonogenic human tumour cells and haematopoietic precursor cells. Br J Cancer 1998; 78: 739–744.

3. Faircloth G, Grant W, Nam S, Jimeno J, Manzanares I, Rinehart K . Schedule-dependency of aplidine, a marine depsipeptide with antitumor activity. Proc Am Assoc Cancer Res 1999; 40: 394.

4. Paz-Ares L, Anthony A, Pronk L, Twelves C, Alonso S, Cortes-Funes H et al. Phase I clinical and pharmacokinetic study of aplidine, a new marine didemnin, administered as 24-hour infusion weekly. Clin Cancer Res 2000; 6(Suppl): 4509.

5. Raymond E, Ady-Vago N, Baudin E, Ribrag V, Faivre S, Lecot F et al. A phase I and pharmacokinetic study of aplidine given as a 24-hour continuous infusion every other week in patients with solid tumor and lymphoma. Clin Cancer Res 2000; 6(Suppl): 4510.

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