Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F-Reference-Cited by-同舟云学术

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Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F

Published:2012-07-22 Issue:8 Volume:19 Page:754-759
ISSN:1545-9993
Container-title:Nature Structural & Molecular Biology
language:en
Short-container-title:Nat Struct Mol Biol

Author:

Bandaranayake Rajintha M,Ungureanu Daniela,Shan Yibing,Shaw David E,Silvennoinen Olli,Hubbard Stevan R

Publisher

Springer Science and Business Media LLC

Subject

Molecular Biology,Structural Biology

Link

http://www.nature.com/articles/nsmb.2348.pdf

Reference47 articles.

1. Ghoreschi, K., Laurence, A. & O'Shea, J.J. Janus kinases in immune cell signaling. Immunol. Rev. 228, 273–287 (2009).

2. Levy, D.E. & Darnell, J.E. Jr. Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol. 3, 651–662 (2002).

3. Lucet, I.S. et al. The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor. Blood 107, 176–183 (2006).

4. Boggon, T.J., Li, Y., Manley, P.W. & Eck, M.J. Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog. Blood 106, 996–1002 (2005).

5. Williams, N.K. et al. Dissecting specificity in the Janus kinases: the structures of JAK-specific inhibitors complexed to the JAK1 and JAK2 protein tyrosine kinase domains. J. Mol. Biol. 387, 219–232 (2009).

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