The dynamic epitranscriptome: N6-methyladenosine and gene expression control
Author:
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Link
http://www.nature.com/articles/nrm3785.pdf
Reference123 articles.
1. Lewis, J. D. et al. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA. Cell 69, 905–914 (1992).
2. Pawson, T. & Scott, J. D. Protein phosphorylation in signaling — 50 years and counting. Trends Biochem. Sci. 30, 286–290 (2005).
3. Meyer, K. D. et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons. Cell 149, 1635–1646 (2012). Provides the first demonstration that m6A is a widespread modification in mammalian mRNAs and reveals that m6A is highly enriched in sites surrounding stop codons and in UTRs. Also identifies many methylated ncRNAs, which were not previously known to contain m6A.
4. Dominissini, D. et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A–seq. Nature 485, 201–206 (2012). Demonstrates, together with reference 3, that m6A is a pervasive feature of the transcriptome, which exhibits a unique distribution within mRNAs. Identifies YTHDF2, YTFDF3 and HuR as potential m6A binding proteins.
5. Jia, G. et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nature Chem. Biol. 7, 885–887 (2011). Reveals that the obesity-associated protein FTO is capable of demethylating m6A residues in mRNA and points to the reversibility of this modification.
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