Gene expression elucidates functional impact of polygenic risk for schizophrenia
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Published:2016-09-26
Issue:11
Volume:19
Page:1442-1453
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ISSN:1097-6256
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Container-title:Nature Neuroscience
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language:en
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Short-container-title:Nat Neurosci
Author:
Fromer MenachemORCID, Roussos Panos, Sieberts Solveig K, Johnson Jessica S, Kavanagh David H, Perumal Thanneer M, Ruderfer Douglas M, Oh Edwin C, Topol Aaron, Shah Hardik R, Klei Lambertus L, Kramer Robin, Pinto DalilaORCID, Gümüş Zeynep H, Cicek A Ercument, Dang Kristen K, Browne Andrew, Lu Cong, Xie Lu, Readhead Ben, Stahl Eli A, Xiao Jianqiu, Parvizi Mahsa, Hamamsy Tymor, Fullard John F, Wang Ying-Chih, Mahajan Milind C, Derry Jonathan M J, Dudley Joel T, Hemby Scott E, Logsdon Benjamin AORCID, Talbot Konrad, Raj Towfique, Bennett David A, De Jager Philip L, Zhu Jun, Zhang Bin, Sullivan Patrick FORCID, Chess Andrew, Purcell Shaun M, Shinobu Leslie A, Mangravite Lara MORCID, Toyoshiba Hiroyoshi, Gur Raquel E, Hahn Chang-Gyu, Lewis David A, Haroutunian Vahram, Peters Mette A, Lipska Barbara K, Buxbaum Joseph D, Schadt Eric E, Hirai Keisuke, Roeder Kathryn, Brennand Kristen J, Katsanis Nicholas, Domenici Enrico, Devlin Bernie, Sklar Pamela
Publisher
Springer Science and Business Media LLC
Subject
General Neuroscience
Reference134 articles.
1. McGrath, J., Saha, S., Chant, D. & Welham, J. Schizophrenia: a concise overview of incidence, prevalence, and mortality. Epidemiol. Rev. 30, 67–76 (2008). 2. Kirov, G. CNVs in neuropsychiatric disorders. Hum. Mol. Genet. 24, R45–R49 (2015). 3. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature 511, 421–427 (2014). 4. Purcell, S.M. et al. Common polygenic variation contributes to risk of schizophrenia and bipolar disorder. Nature 460, 748–752 (2009). 5. Purcell, S.M. et al. A polygenic burden of rare disruptive mutations in schizophrenia. Nature 506, 185–190 (2014).
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