Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance

Author:

Kilic M,Kasperczyk H,Fulda S,Debatin K-M

Publisher

Springer Science and Business Media LLC

Subject

Cancer Research,Genetics,Molecular Biology

Reference48 articles.

1. Akakura N, Kobayashi M, Horiuchi I, Suzuki A, Wang J, Chen J et al. (2001). Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. Cancer Res 61: 6548–6554.

2. Alvarez-Tejado M, Naranjo-Suarez S, Jimenez C, Carrera AC, Landazuri MO, Del Peso L . (2001). Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis. J Biol Chem 276: 22368–22374.

3. An GW, Kanekal Meera, Simon MC, Maltepe E, Blagosklonny MV, Neckers ML . (1998). Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha. Nature 392: 405–408.

4. Blum R, Hirsch J-J, Amariglio N, Rechavi G, Kloog Y . (2005). Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death. Cancer Res 65: 3999.

5. Bruick RK . (2000). Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci 97: 9082–9087.

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