Transcriptomic analysis of celiac disease treatment with transglutaminase 2 inhibitor
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Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41590-024-01870-5.pdf
Reference5 articles.
1. Besser, H. A. & Khosla, C. Celiac disease: mechanisms and emerging therapeutics. Trends Pharmacol. Sci. 44, 949–962 (2023). A review article that presents current understanding of CeD pathogenesis and how this knowledge is being harnessed for therapeutic design and development.
2. Dotsenko, V. & Viiri, K. Genome-wide transcriptomic analysis of intestinal mucosa in celiac disease patients on a gluten-free diet and post gluten challenge. Cell Mol. Gastroenterol. Hepatol. 11, 13–32 (2021). This paper reports gluten challenge-induced duodenal biopsy transcriptomic changes and created a molecular morphometric tool to measure mucosal injury objectively.
3. Schuppan, D. & Mäki, M. A randomized trial of a transglutaminase 2 inhibitor for celiac disease. N. Engl. J. Med. 385, 35–45 (2021). This paper reports a proof-of-concept trial that treatment with ZED1227 attenuates gluten-induced mucosal damage in patients with CeD.
4. Sollid, L. M. & Jabri, B. Triggers and drivers of autoimmunity: lessons from coeliac disease. Nat. Rev. Immunol. 13, 294–302 (2013). A review article that presents CeD as a model for autoimmunity in general.
5. Christophersen, A. & Davis, M. M. Distinct phenotype of CD4+ cells driving celiac disease identified in multiple autoimmune conditions. Nat. Med. 25, 734–737 (2019). This paper reports a way to identify CD4+ T cells specific for environmental disease-driving antigens in autoimmune conditions.
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