Genetics determines how environmental change alters immune phenotypes
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Publisher
Springer Science and Business Media LLC
Link
https://www.nature.com/articles/s41590-024-01879-w.pdf
Reference5 articles.
1. Gause, W. C., Rothlin, C. & Loke, P. Heterogeneity in the initiation, development and function of type 2 immunity. Nat. Rev. Immunol. 20, 603–614 (2020). A review article examining heterogeneity during type 2 immune responses.
2. Lin, J.-D. et al. Rewilding Nod2 and Atg16l1 mutant mice uncovers genetic and environmental contributions to microbial responses and immune cell composition. Cell Host Microbe 27, 830–840 (2020). Previous work from our group demonstrating that genetic factors influence cytokine responses, and environmental factors alter cellular composition.
3. Aguirre-Gamboa, R. et al. Differential effects of environmental and genetic factors on T and B cell immune traits. Cell Rep. 17, 2474–2487 (2016). A key article demonstrating differential effect of environment versus genetics on human T cell and B cell traits.
4. Graham, A. L. Naturalizing mouse models for immunology. Nat. Immunol. 22, 111–117 (2021). A review article on the importance of environmental models in studying immune function.
5. Downie, A. E. et al. Spatiotemporal-social association predicts immunological similarity in rewilded mice. Sci. Adv. 9, eadh8310 (2023). Recent work demonstrating that social behavior can influence immune phenotype.
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