Single-cell and multivariate approaches in genetic perturbation screens
Author:
Publisher
Springer Science and Business Media LLC
Subject
Genetics (clinical),Genetics,Molecular Biology
Link
http://www.nature.com/articles/nrg3768.pdf
Reference155 articles.
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3. Carpenter, A. E. & Sabatini, D. M. Systematic genome-wide screens of gene function. Nature Rev. Genet. 5, 11–22 (2004).
4. Loo, L.-H., Wu, L. F. & Altschuler, S. J. Image-based multivariate profiling of drug responses from single cells. Nature Methods 4, 445–453 (2007). This paper identifies drug targets using a SVM-based method that takes into account the multivariate feature set of single cells in a population.
5. Boutros, M., Bras, L. P. & Huber, W. Analysis of cell-based RNAi screens. Genome Biol. 7, R66 (2006).
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