Author:
Lee Dong-Wook,Lim Hyun-Mook,Lee Joong-Yub,Min Kyung-Bok,Shin Choong-Ho,Lee Young-Ah,Hong Yun-Chul
Abstract
AbstractPhthalates are well-known endocrine-disrupting chemicals. Many detrimental health effects of phthalates were investigated, but studies on the association of phthalates with obesity in children showed inconsistent results. Thus, this systematic review and meta-analysis were performed to clarify whether prenatal and postnatal exposures to phthalates are associated with physical growth disturbances in children. We performed the systematic review and meta-analysis following the PRISMA 2020 statement guidelines, and found 39 studies that met our inclusion criteria, including 22 longitudinal and 17 cross-sectional studies. We observed a significant negative association between the prenatal exposure to DEHP and the body mass index (BMI) z-score of the offspring (β = − 0.05; 95% CI: − 0.10, − 0.001) in the meta-analysis, while no significant association between the prenatal exposure to DEHP and the body fat percentage of the offspring was observed (β = 0.01; 95% CI: − 0.41, 0.44). In the systematic review, studies on the association between phthalates exposure in childhood and obesity were inconsistent. Prenatal exposure to phthalates was found to be associated with decreased BMI z-score in children, but not associated with body fat percentage. Our findings suggest that phthalates disturb the normal muscle growth of children, rather than induce obesity, as previous studies have hypothesized.
Publisher
Springer Science and Business Media LLC
Reference99 articles.
1. Holland, M. Socio-economic assessment of phthalates. Organization for Economic Co-operation and Development Environment Working Papers No. 133.
2. Erythropel, H. C., Maric, M., Nicell, J. A., Leask, R. L. & Yargeau, V. Leaching of the plasticizer di (2-ethylhexyl) phthalate (DEHP) from plastic containers and the question of human exposure. Appl. Microbiol. Biotechnol. 98, 9967–9981 (2014).
3. Lorz, P. M. et al. Ullmann’s Encyclopedia of Industrial Chemistry (Wiley-VCH Verlag GmbH & Co. KGaA, Hoboken, 2000).
4. Silva, M. J. et al. Urinary levels of seven phthalate metabolites in the US population from the National Health and Nutrition Examination Survey (NHANES) 1999–2000. Environ. Health Perspect. 112, 331–338 (2004).
5. Borch, J., Metzdorff, S. B., Vinggaard, A. M., Brokken, L. & Dalgaard, M. Mechanisms underlying the anti-androgenic effects of diethylhexyl phthalate in fetal rat testis. Toxicology 223, 144–155 (2006).
Cited by
24 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献