Immune cell characteristics and cytokine responses in adult HIV-negative tuberculous meningitis: an observational cohort study

Author:

van Laarhoven ArjanORCID,Dian Sofiati,van Dorp Suzanne,Purnama Feby,Koeken Valerie A. C. M.ORCID,Diandini Emira,Utami Fitria,Livia Resvi,Apriani Lika,Ardiansyah Edwin,ter Horst Rob,Netea Mihai G.ORCID,Achmad Tri Hanggono,Hill Philip C.,Ruslami Rovina,Alisjahbana Bachti,Ussher James E.ORCID,Indrati Agnes,Verrall AyeshaORCID,Ganiem Ahmad Rizal,van Crevel Reinout

Funder

Radboud Universiteit

Ministry of Research, Technology and Higher Education, Indonesia

EC | European Research Council

Nederlandse Organisatie voor Wetenschappelijk Onderzoek

Ministry of Research, Technology and Higher Education, Indonesia (PKSLN grant(

United States Agency for International Development

Koninklijke Nederlandse Akademie van Wetenschappen

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference29 articles.

1. Wilkinson, R. J. et al. Tuberculous meningitis. Nat Rev Neurol 13, 581–598 (2017).

2. Prasad, K., Singh, M. B. & Ryan, H. Corticosteroids for managing tuberculous meningitis. Cochrane Database Syst Rev 4, CD002244 (2016).

3. Tobin, D. M. et al. Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections. Cell 148, 434–446 (2012).

4. Mai, N. T. et al. A randomised double blind placebo controlled phase 2 trial of adjunctive aspirin for tuberculous meningitis in HIV-uninfected adults. Elife (Cambridge) 7, 4440 (2018).

5. van Laarhoven, A. et al. Clinical Parameters, Routine Inflammatory Markers, and LTA4H Genotype as Predictors of Mortality Among 608 Patients With Tuberculous Meningitis in Indonesia. Journal of Infectious Diseases 215, 1029–1039 (2017).

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