Abstract
AbstractOur objective was to evaluate the independent prognostic value of a novel MRI biomarker—objectively diagnosed diffuse white matter abnormality volume (DWMA; diffuse excessive high signal intensity)—for prediction of motor outcomes in very preterm infants. We prospectively enrolled a geographically-based cohort of very preterm infants without severe brain injury and born before 32 weeks gestational age. Structural brain MRI was obtained at term-equivalent age and DWMA volume was objectively quantified using a published validated algorithm. These results were compared with visually classified DWMA. We used multivariable linear regression to assess the value of DWMA volume, independent of known predictors, to predict motor development as assessed using the Bayley Scales of Infant & Toddler Development, Third Edition at 3 years of age. The mean (SD) gestational age of the cohort was 28.3 (2.4) weeks. In multivariable analyses, controlling for gestational age, sex, and abnormality on structural MRI, DWMA volume was an independent prognostic biomarker of Bayley Motor scores ($$\beta $$
β
= −12.59 [95% CI −18.70, −6.48] R2 = 0.41). Conversely, visually classified DWMA was not predictive of motor development. In conclusion, objectively quantified DWMA is an independent prognostic biomarker of long-term motor development in very preterm infants and warrants further study.
Funder
National Institutes of Health
Publisher
Springer Science and Business Media LLC
Reference48 articles.
1. Shevell, M. Cerebral palsy to cerebral palsy spectrum disorder: Time for a name change?. Neurology https://doi.org/10.1212/WNL.0000000000006747 (2018).
2. Honeycutt, A. A. et al. in Using survey data to study disability: results from the national health interview survey on disability, Vol. 3 (eds B.M. Altman, S.N. Barnartt, G.E. Hendershot, & S.A. Larson) 207–228 (Emerald Group Publishing Limited, 2003).
3. Sellier, E. et al. Decreasing prevalence in cerebral palsy: a multi-site European population-based study, 1980 to 2003. Dev. Med. Child. Neurol. 58, 85–92. https://doi.org/10.1111/dmcn.12865 (2016).
4. Williams, J., Lee, K. J. & Anderson, P. J. Prevalence of motor-skill impairment in preterm children who do not develop cerebral palsy: a systematic review. Dev. Med. Child. Neurol. 52, 232–237. https://doi.org/10.1111/j.1469-8749.2009.03544.x (2010).
5. Van Hus, J. W., Potharst, E. S., Jeukens-Visser, M., Kok, J. H. & Van Wassenaer-Leemhuis, A. G. Motor impairment in very preterm-born children: links with other developmental deficits at 5 years of age. Dev. Med. Child. Neurol. 56, 587–594 (2014).
Cited by
13 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献