Author:
Nøst Therese H.,Holden Marit,Dønnem Tom,Bøvelstad Hege,Rylander Charlotta,Lund Eiliv,Sandanger Torkjel M.
Abstract
AbstractRecent studies have indicated that there are functional genomic signals that can be detected in blood years before cancer diagnosis. This study aimed to assess gene expression in prospective blood samples from the Norwegian Women and Cancer cohort focusing on time to lung cancer diagnosis and metastatic cancer using a nested case–control design. We employed several approaches to statistically analyze the data and the methods indicated that the case–control differences were subtle but most distinguishable in metastatic case–control pairs in the period 0–3 years prior to diagnosis. The genes of interest along with estimated blood cell populations could indicate disruption of immunological processes in blood. The genes identified from approaches focusing on alterations with time to diagnosis were distinct from those focusing on the case–control differences. Our results support that explorative analyses of prospective blood samples could indicate circulating signals of disease-related processes.
Funder
Norges Forskningsråd
European Research Council,European Union
Publisher
Springer Science and Business Media LLC
Reference51 articles.
1. Ferlay, J. et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int. J. Cancer 144, 1941–1953 (2019).
2. Cancer Registry of Norway. Cancer in Norway 2017—Cancer incidence, mortality, survival and prevalence in Norway, Oslo, Norway (2017). https://www.kreftregisteret.no/globalassets/cancer-in-norway/2017/cin-2017.pdf.
3. Lortet-Tieulent, J. et al. International trends in lung cancer incidence by histological subtype: Adenocarcinoma stabilizing in men but still increasing in women. Lung Cancer 84, 13–22 (2014).
4. Cancer Research UK. Lung cancer statistics (2018) (accessed September 2018); https://www.cancerresearchuk.org/health-professional/cancer-statistics/statistics-by-cancer-type/lung-cancer.
5. Peto, R. et al. Smoking, smoking cessation, and lung cancer in the UK since 1950: Combination of national statistics with two case-control studies. BMJ 321, 323–329 (2000).
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献