Microscale pressure measurements based on an immiscible fluid/fluid interface

Author:

Yang Jing,Duan Xing,Fraser Andrew K.ORCID,Choudhury Mohammad IkbalORCID,Ewald Andrew J.,Li RongORCID,Sun Sean X.ORCID

Abstract

AbstractA method of microscale pressure measurement based on immiscible fluid/fluid interface is proposed. This method utilizes observed curvature changes in a fluid/fluid interface, and can accurately report hydraulic pressure in fluids at length scales of 10 microns. The method is especially suited for measuring fluid pressure in micro-scale biological samples. Using this method, we probe fluid pressure build up in epithelial domes, murine mammary gland organoids embedded in hydrogel, and lumen pressure in the developing mouse embryo. Results reveal that the pressure developed across epithelial barriers is on the order of 100~300 Pa, and is modulated by ion channel activity.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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