Author:
Ren Ping,Hou Gangqiang,Ma Manxiu,Zhuang Yuchuan,Huang Jiayin,Tan Meiling,Wu Donghui,Luo Guozhi,Zhang Zhiguo,Rong Han
Abstract
AbstractRisky decision-making is critical to survival and development, which has been compromised in elderly populations. However, the neural substrates of altered financial risk-taking behavior in aging are still under-investigated. Here we examined the intrinsic putamen network in modulating risk-taking behaviors of Balloon Analogue Risk Task in healthy young and older adults using resting-state fMRI. Compared with the young group, the elderly group showed significantly different task performance. Based on the task performance, older adults were further subdivided into two subgroups, showing young-like and over-conservative risk behaviors, regardless of cognitive decline. Compared with young adults, the intrinsic pattern of putamen connectivity was significantly different in over-conservative older adults, but not in young-like older adults. Notably, age-effects on risk behaviors were mediated via the putamen functional connectivity. In addition, the putamen gray matter volume showed significantly different relationships with risk behaviors and functional connectivity in over-conservative older adults. Our findings suggest that reward-based risky behaviors might be a sensitive indicator of brain aging, highlighting the critical role of the putamen network in maintaining optimal risky decision-making in age-related cognitive decline.
Funder
Natural Science Foundation of Guangdong Province
Science, Technology and Innovation Commission of Shenzhen Municipality
Sanming Project of Medicine in Shenzhen
Publisher
Springer Science and Business Media LLC
Cited by
1 articles.
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