Author:
Nishigori Hidekazu,Nishigori Toshie,Obara Taku,Suzuki Taeko,Mori Miyuki,Imaizumi Karin,Murata Tsuyoshi,Kyozuka Hyo,Ogata Yuka,Sato Akiko,Shinoki Kosei,Yasumura Seiji,Hosoya Mitsuaki,Hashimoto Koichi,Fujimori Keiya,Kamijima Michihiro,Yamazaki Shin,Ohya Yukihiro,Kishi Reiko,Yaegashi Nobuo,Hashimoto Koichi,Mori Chisato,Ito Shuichi,Yamagata Zentaro,Inadera Hidekuni,Nakayama Takeo,Sofue Tomotaka,Shima Masayuki,Nakamura Hiroshige,Suganuma Narufumi,Kusuhara Koichi,Katoh Takahiko,
Abstract
AbstractWe evaluated the association between maternal prenatal folic acid supplement use/dietary folate intake and cognitive development in 4-year-old offspring (N = 3445) using data from the Japan Environment and Children’s Study. Cognitive development was evaluated using the Kyoto Scale of Psychological Development 2001. Multiple regression analysis revealed that offspring of mothers who started using folic acid supplements pre-conception had a significantly higher language-social developmental quotient (DQ) (partial regression coefficient 1.981, 95% confidence interval 0.091 to 3.872) than offspring of mothers who did not use such supplements at any time throughout their pregnancy (non-users). Offspring of mothers who started using folic acid supplements within 12 weeks of gestation had a significantly higher cognitive-adaptive (1.489, 0.312 to 2.667) and language-social (1.873, 0.586 to 3.159) DQ than offspring of non-users. Regarding daily dietary folate intake from preconception to early pregnancy, multiple regression analysis revealed that there was no significant association with any DQ area in the 200 to < 400 µg and the ≥ 400 µg groups compared with the < 200 µg group. Maternal prenatal folic acid supplementation starting within 12 weeks of gestation (but not adequate dietary folate intake from preconception to early pregnancy) is positively associated with cognitive development in 4-year-old offspring.
Publisher
Springer Science and Business Media LLC