Risk of head and neck cancer in patients with peptic ulcers and the effect of Helicobacter pylori treatment

Author:

Lu Yen-Ting,Hsin Chung-Han,Lu Ying-Chou,Wu Meng-Che,Huang Jing-Yang,Huang Cheng‐Chen,Wang Po-Hui,Yang Shun-Fa

Abstract

AbstractIt remained inconclusive whether patients with peptic ulcer disease had a higher risk of head and neck cancer (HNC). Therefore, we enrolled 109,360 patients with peptic ulcer disease and matched for age and sex with 218,720 controls from the Taiwan National Health Insurance Research Database between January 1, 1997 and December 31, 2013.The HNC incidence rate was 1.33-fold higher in the peptic ulcer group than in the control group (7.52 vs. 5.68 per 100,00 person-years; crude relative risk: 1.33; 95% confidence interval [CI]: 1.08–1.63) after > 6 years of follow-up. However, in the peptic ulcer subgroup with H. pylori treatment, HNC risk was not significantly different from that of the control group (crude relative risk: 1.12; 95% CI: 0.86–1.46). Moreover, the population with peptic ulcers had the highest risk of laryngeal and hypopharyngeal cancer (adjusted HR: 2.27 [95% CI: 1.16–4.44] and 2.00 [95% CI, 1.13–3.55]), respectively. This observational study suggested that peptic ulcer disease is associated with an increased incidence of laryngeal and hypopharyngeal cancer and H. pylori treatment may have a role in preventing HNC in patients with peptic ulcer disease.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference47 articles.

1. Marshall, B. J. & Warren, J. R. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet 1, 1311–1315 (1984).

2. Sepulveda, A. R. & Graham, D. Y. Role of Helicobacter pylori in gastric carcinogenesis. Gastroenterol. Clin. N. Am. 31, 517–553 (2002).

3. Stolte, S. E. A. M. The significanceof Helicobacter pylori in relation to gastric cancer and lymphoma. Eur. J. Gastroenterol. Hepatol. 7, 318–321 (1995).

4. Kuipers, E. J. Helicobacter pylori and gastric carcinogenesis. Scand. J. Gastroenterol. 218, 103–105 (1996).

5. Graham, D. Y. Helicobacter pylori infection is the primary cause of gastric cancer. J. Gastroenterol. Hepatol. 35, 90–97 (2000).

Cited by 5 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3