Abstract
AbstractCerebral aneurysms are potentially life threatening and nowadays treated by a catheter-guided coiling or by a neurosurgical clipping intervention. Here, we propose a helically shaped magnetic micro-robot, which can be steered by magnetic fields in an untethered manner and could be applied for a novel coiling procedure. This is shown by navigating the micro-robot through an additively manufactured phantom of a human cerebral aneurysm. The magnetic fields are applied with a magnetic particle imaging (MPI) scanner, which allows for the navigation and tomographic visualization by the same machine. With MPI the actuation process can be visualized with a localization accuracy of 0.68 mm and an angiogram can be acquired both without any radiation exposure. First in-vitro phantom experiments are presented, showing an idea of a robot conducted treatment of cerebral aneurysms.
Funder
Bundesministerium für Bildung, Wissenschaft und Forschung
Universität zu Lübeck
Publisher
Springer Science and Business Media LLC
Reference52 articles.
1. Rey, J. et al. Feasibility of stomach exploration with a guided capsule endoscope. Endoscopy 42, 541–545 (2010).
2. Munoz, F., Alici, G. & Li, W. A review of drug delivery systems for capsule endoscopy. Adv. Drug Deliv. Rev. 71, 77–85 (2014).
3. Sitti, M. et al. Biomedical applications of untethered mobile milli/microrobots. Proc. IEEE 103, 205–224 (2015).
4. Bakenecker, A. C. et al. Actuation and visualization of a magnetically coated swimmer with magnetic particle imaging. J. Magn. Magn. Mater. 473, 495–500 (2019).
5. Lee, S. et al. Fabrication and characterization of a magnetic drilling actuator for navigation in a three-dimensional phantom vascular network. Sci. Rep. 8, 1–10 (2018).
Cited by
42 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献