Author:
Tian Jin-Ze,Xing Sheng,Feng Jing-Yi,Yang Shu-Hua,Ding Yan-Fu,Huang Xue-Ting,Yang Jin-Shu,Yang Wei-Jun
Abstract
AbstractIn the adult pancreas, the presence of progenitor or stem cells and their potential involvement in homeostasis and regeneration remains unclear. Here, we identify that SET domain-containing protein 4 (SETD4), a histone lysine methyltransferase, is expressed in a small cell population in the adult mouse pancreas. Genetic lineage tracing shows that during pancreatic development, descendants of SETD4+ cells make up over 70% of pancreatic cells and then contribute to each pancreatic lineage during pancreatic homeostasis. SETD4+ cells generate newborn acinar cells in response to cerulein-induced pancreatitis in acinar compartments. Ablation of SETD4+ cells compromises regeneration of acinar cells, in contrast to controls. Our findings provide a new cellular narrative for pancreatic development, homeostasis and response to injury via a small SETD4+ cell population. Potential applications may act to preserve pancreatic function in case of pancreatic disease and/or damage.
Funder
National Key R & D Program of China
National Major Research and Development Projects of China
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
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