Repeated neonatal isoflurane exposures in the mouse induce apoptotic degenerative changes in the brain and relatively mild long-term behavioral deficits

Author:

Maloney Susan E.ORCID,Yuede Carla M.,Creeley Catherine E.,Williams Sasha L.,Huffman Jacob N.,Taylor George T.,Noguchi Kevin N.,Wozniak David F.

Funder

U.S. Department of Health & Human Services | National Institutes of Health

U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference68 articles.

1. FDA Safety Communication. FDA Drug Safety Communication: FDA review results in new warnings about using general anesthetics and sedation drugs in young children and pregnant women. https://www.fda.gov/Drugs/DrugSafety/ucm532356.htm (2016).

2. FDA Safety Communication. FDA Drug Safety Communication: FDA approves label changes for use of general anesthetic and sedation drugs in young children. https://www.fda.gov/Drugs/DrugSafety/ucm554634.htm (2017).

3. DiMaggio, C., Sun, L. S., Ing, C. & Li, G. Pediatric anesthesia and neurodevelopmental impairments: a Bayesian meta-analysis. J Neurosurg Anesthesiol 24, 376–381 (2012).

4. Davidson, A. J. et al. Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial. Lancet 387, 239–250 (2016).

5. Ing, C. et al. Duration of general anaesthetic exposure in early childhood and long-term language and cognitive ability. Br J Anaesth 119, 532–540 (2017).

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