Structures of PPARγ complexed with lobeglitazone and pioglitazone reveal key determinants for the recognition of antidiabetic drugs
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-017-17082-x.pdf
Reference41 articles.
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3. Han, L., Shen, W. J., Bittner, S., Kraemer, F. B. & Azhar, S. PPARs: regulators of metabolism and as therapeutic targets in cardiovascular disease. Part II: PPAR-beta/delta and PPAR-gamma. Future Cardiol 13, 279–296, https://doi.org/10.2217/fca-2017-0019 (2017).
4. Kota, B. P., Huang, T. H. & Roufogalis, B. D. An overview on biological mechanisms of PPARs. Pharmacol Res 51, 85–94, https://doi.org/10.1016/j.phrs.2004.07.012 (2005).
5. Nolte, R. T. et al. Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature 395, 137–143, https://doi.org/10.1038/25931 (1998).
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