Author:
Mihara Akane,Ohara Tomoyuki,Hata Jun,Chen Sanmei,Honda Takanori,Tamrakar Sonam,Isa Akiko,Wang Dongmei,Shimizu Kuniyoshi,Katakura Yoshinori,Yonemoto Koji,Nakao Tomohiro,Kitazono Takanari,Ninomiya Toshiharu
Abstract
AbstractWe examined the association of serum s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH) (methionine metabolites), and their ratio on the risk of dementia and death in a community-dwelling population of older Japanese individuals. 1371 residents of Hisayama, Japan, aged 65 years or older and without dementia, were followed for a median of 10.2 years (2007–2017). We divided serum SAM, SAH, and SAM/SAH ratio into quartiles. Cox proportional hazards models were used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) of serum SAM, SAH, and SAM/SAH ratio levels on the risk of a composite outcome of all-cause dementia or death, and each outcome. During the follow-up, 635 participants developed all-cause dementia and/or died, of which 379 participants developed dementia and 394 deaths occurred. The multivariable-adjusted HRs of the composite outcome decreased significantly with increasing serum SAM levels (P for trend = 0.01), while they increased significantly with higher serum SAH levels (P for trend = 0.03). Higher serum SAM/SAH ratio levels were significantly associated with a lower risk of the composite outcome (P for trend = 0.002), as well as with lower risk of each outcome. Our findings suggest that the balance of methionine metabolites may closely associate with the risk of dementia and death.
Funder
the Ministry of Education, Culture, Sports, Science and Technology of Japan
Fukuoka Prefecture and Kurume City in Japan
the Health and Labour Sciences Research Grants of the Ministry of Health, Labour and Welfare of Japan
the Japan Agency for Medical Research and Development
Publisher
Springer Science and Business Media LLC
Cited by
4 articles.
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