Author:
Magis Andrew T.,Rappaport Noa,Conomos Matthew P.,Omenn Gilbert S.,Lovejoy Jennifer C.,Hood Leroy,Price Nathan D.
Abstract
AbstractWe analyzed 1196 proteins in longitudinal plasma samples from participants in a commercial wellness program, including samples collected pre-diagnosis from ten cancer patients and 69 controls. For three individuals ultimately diagnosed with metastatic breast, lung, or pancreatic cancer, CEACAM5 was a persistent longitudinal outlier as early as 26.5 months pre-diagnosis. CALCA, a biomarker for medullary thyroid cancer, was hypersecreted in metastatic pancreatic cancer at least 16.5 months pre-diagnosis. ERBB2 levels spiked in metastatic breast cancer between 10.0 and 4.0 months pre-diagnosis. Our results support the value of deep phenotyping seemingly healthy individuals in prospectively inferring disease transitions.
Funder
Arivale
Institute for Systems Biology
National Institutes of Health
Andy Hill Cancer Research Endowment Fund
Publisher
Springer Science and Business Media LLC
Cited by
13 articles.
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