Author:
Garcia-Calavaro Christian,Harrison Lee H.,Pokutnaya Darya,Mair Christina F.,Brooks Maria M.,van Panhuis Wilbert
Abstract
AbstractInfluenza seasonality is caused by complex interactions between environmental factors, viral mutations, population crowding, and human travel. To date, no studies have estimated the seasonality and latitudinal patterns of seasonal influenza in Chile. We obtained influenza-like illness (ILI) surveillance data from 29 Chilean public health networks to evaluate seasonality using wavelet analysis. We assessed the relationship between the start, peak, and latitude of the ILI epidemics using linear and piecewise regression. To estimate the presence of incoming and outgoing traveling waves (timing vs distance) between networks and to assess the association with population size, we used linear and logistic regression. We found a north to south gradient of influenza and traveling waves that were present in the central, densely populated region of Chile. Our findings suggest that larger populations in central Chile drive seasonal influenza epidemics.
Funder
Comisión Nacional de Investigación Científica y Tecnológica
Publisher
Springer Science and Business Media LLC
Reference49 articles.
1. World Health Organization. Influenza (Seasonal) Fact Sheet. [Internet]. [cited 2021 Jan 22]. https://www.who.int/news-room/fact-sheets/detail/influenza-(seasonal).
2. Lipsitch, M. & Viboud, C. Influenza seasonality: lifting the fog. Proc. Natl. Acad. Sci. U.S.A. 106, 3645–3646 (2009).
3. Lofgren, E., Fefferman, N. H., Naumov, Y. N., Gorski, J. & Naumova, E. N. Influenza seasonality: underlying causes and modeling theories. J. Virol. 81, 5429–5436 (2007).
4. Lowen, A. C., Mubareka, S., Steel, J. & Palese, P. Influenza virus transmission is dependent on relative humidity and temperature. PLoS Pathog. 3, 1470–1476 (2007).
5. Viboud, C. et al. Synchrony, waves, and spatial hierarchies in the spread of influenza. Science (New York, NY) 312, 447–451 (2006).