Author:
Lu Ming-Ying,Chen Chun-Ting,Shih Yu-Lueng,Tsai Pei-Chien,Hsieh Meng-Hsuan,Huang Chung-Feng,Yeh Ming-Lun,Huang Ching-I,Wang Shu-Chi,Tsai Yi-Shan,Ko Yu-Min,Lin Ching-Chih,Chen Kuan-Yu,Wei Yu-Ju,Hsu Po-Yao,Hsu Cheng-Ting,Jang Tyng-Yuan,Liu Ta-Wei,Liang Po-Cheng,Hsieh Ming-Yen,Lin Zu-Yau,Chen Shinn-Cherng,Huang Jee-Fu,Dai Chia-Yen,Chuang Wan-Long,Yu Ming-Lung,Chang Wen-Yu
Abstract
AbstractThe spreading of viral hepatitis among injecting drug users (IDU) is an emerging public health concern. This study explored the prevalence and the risks of hepatitis B virus (HBV), hepatitis C virus (HCV) and hepatitis D virus (HDV) among IDU-dominant prisoners in Taiwan. HBV surface antigen (HBsAg), antibodies to HCV (anti-HCV) and HDV (anti-HDV), viral load and HCV genotypes were measured in 1137(67.0%) of 1697 prisoners. 89.2% of participants were IDUs and none had HIV infection. The prevalence of HBsAg, anti-HCV, dual HBsAg/anti-HCV, HBsAg/anti-HDV, and triple HBsAg/anti-HCV/anti-HDV was 13.6%, 34.8%, 4.9%, 3.4%, and 2.8%, respectively. HBV viremia rate was significantly lower in HBV/HCV-coinfected than HBV mono-infected subjects (66.1% versus 89.9%, adjusted odds ratio/95% confidence intervals [aOR/CI] = 0.27/0.10–0.73). 47.5% anti-HCV-seropositive subjects (n = 396) were non-viremic, including 23.2% subjects were antivirals-induced. The predominant HCV genotypes were genotype 6(40.9%), 1a(24.0%) and 3(11.1%). HBsAg seropositivity was negatively correlated with HCV viremia among the treatment naïve HCV subjects (44.7% versus 72.4%, aOR/CI = 0.27/0.13–0.58). Anti-HCV seropositivity significantly increased the risk of anti-HDV-seropositivity among HBsAg carriers (57.1% versus 7.1%, aOR/CI = 15.73/6.04–40.96). In conclusion, IUDs remain as reservoirs for multiple hepatitis viruses infection among HIV-uninfected prisoners in Taiwan. HCV infection increased the risk of HDV infection but suppressed HBV replication in HBsAg carriers. An effective strategy is mandatory to control the epidemic in this high-risk group.
Funder
Taiwan Liver Research Foundation
Kaohsiung Medical University
Kaohsiung Medical University Hospital
Center for Cancer Research of Kaohsiung Medical University
Liquid Biopsy and Cohort Research Center of Kaohsiung Medical University
Publisher
Springer Science and Business Media LLC
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献