Author:
Antończyk Agnieszka,Kubiak-Nowak Dominika,Borawski Wojciech,Kiełbowicz Zdzisław,Danielewska Monika E.
Abstract
AbstractThe aim was to assess the relationships between cardiovascular activity, corneal pulse characteristics, and corneal biomechanics in rabbits. Seventeen rabbits were randomly assigned to one of two anesthetic regimens to induce differences in arterial blood pressure and heart rate. Experimental protocol included measuring blood flow parameters in the ophthalmic artery by color Doppler imaging, corneal biomechanical parameters using a non-contact tonometer Corvis ST, and the corneal pulse (CP) signal using a non-contact ultrasonic technique. Statistically significantly lower mean values of normalized amplitudes of higher CP harmonics and changes in eight of the twelve corneal biomechanical parameters were observed in the rabbit group with lower arterial blood pressure and higher heart rate, intraocular pressure, and resistive index. The results of partial correlations showed that the CP signal energy and amplitude of its first harmonic correlate with the resistive index, diastolic and mean arterial pressures, whereas no statistically significant correlation was found between any of the CP parameters and intraocular pressure. Our pilot study indicates, for the first time, that non-contact and continuous measuring of corneal pulse allows indirectly assessing changes in cardiovascular activity when the confounding effect of intraocular pressure is eliminated.
Publisher
Springer Science and Business Media LLC
Reference60 articles.
1. Kowalska, M. A., Kasprzak, H. T., Iskander, D. R., Danielewska, M. & Mas, D. Ultrasonic in vivo measurement of ocular surface expansion. IEEE Trans. Biomed. Eng. 58, 674–680. https://doi.org/10.1109/TBME.2010.2100819 (2010).
2. Iskander, D. R. & Kasprzak, H. T. Dynamics in longitudinal eye movements and corneal shape. Ophthalmic Physiol. Opt. 26, 572–579. https://doi.org/10.1111/j.1475-1313.2006.00415.x (2006).
3. Schmetterer, L. F., Lexer, F., Unfried, C. J., Sattmann, H. & Fercher, A. F. Topical measurement of fundus pulsations. Opt. Eng. 34, 711–717. https://doi.org/10.1117/12.193292 (1995).
4. Zuckerman, J. L., Taylor, K. D. & Grossman, H. J. Noncontact detection of ocular pulse-correlation with carotid stenosis. Investig. Ophthalmol. Vis. Sci. 16, 1018–1024 (1977).
5. Bosley, T. M. et al. Amplitude of the ocular pneumoplethysmography waveform is correlated with cardiac output. Stroke 24, 6–9 (1993).
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献