Author:
Mărginean Cristina Oana,Meliţ Lorena Elena,Ghiga Dana Valentina,Săsăran Maria Oana
Abstract
AbstractTE and 2D-SWE are well-documented in studies performed on adults, but those on pediatric patients are limited. The aim of this study was to establish pediatric reference values for liver stiffness using two elastography methods: 2D-SWE and TE. We performed an observational study on 206 healthy children. All children underwent anamnesis, clinical exam, laboratory tests, US exam, TE and 2D-SWE for liver stiffness assessment. The mean liver stiffness value by 2D-SWE for all children was 3.72 ± 0.48 kPa. The mean values ranged between 3.603 ± 0.2678 kPa (3–5 years of age) and 3.774 ± 0.4038 kPa (9–11 years). The reference values varied between 4.1386 kPa (3–5 years of age) and 4.88 kPa (12–15 years). The mean liver stiffness value by TE was 3.797 ± 0.4859 kPa. The values ranged between 3.638 ± 0.4088 kPa (6–8 years of age) and 3.961 ± 0.5695 kPa (15–18 years). The cutoff values varied from 4.4064 kPa (3–5 years of age) to 5.1 kPa (15–18 years). We found a significant positive correlation between E Median values by TE and age [95% CI: 0.1160 to 0.3798, r = 0.2526, p = 0.0002]. Our findings revealed that the mean values of liver stiffness for all children on 2D-SWE and TE were almost identical, 3.72 ± 0.48 kPa versus 3.797 ± 0.4859 kPa.
Publisher
Springer Science and Business Media LLC
Reference40 articles.
1. Dhole, S. D., Kher, A. S., Ghildiyal, R. G. & Tambse, M. P. Chronic Liver Diseases in Children: Clinical Profile and Histology. J. Clin. Diagn. Res. JCDR 9, SC04–07 (2015).
2. Tahir, A., Malik, F. R., Ahmad, I. & Akhtar, P. Aetiological factors of chronic liver disease in children. J. Ayub Med. Coll. Abbottabad JAMC 23, 12–14 (2011).
3. Mărginean, C., Meliț, L., Ghiga, D. & Mărginean, M. Early inflammatory status related to pediatric obesity (STROBE compliant article). Front. Pediatr. 7 (2019).
4. Mărginean, C., Meliț, L., & Meliţ, L. E. New Insights Regarding Genetic Aspects of Childhood Obesity: A Minireview. Front. Pediatr. 6, 271 (2018).
5. Schwimmer, J. B. et al. Paediatric gastroenterology evaluation of overweight and obese children referred from primary care for suspected non-alcoholic fatty liver disease. Aliment. Pharmacol. Ther. 38, 1267–1277 (2013).
Cited by
20 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献