Author:
Yoon Jungbin,Baek Nayeon,Yoo Roh-Eul,Choi Seung Hong,Kim Tae Min,Park Chul-Kee,Park Sung-Hye,Won Jae-Kyung,Lee Joo Ho,Lee Soon Tae,Choi Kyu Sung,Lee Ji Ye,Hwang Inpyeong,Kang Koung Mi,Yun Tae Jin
Abstract
AbstractLocal recurrences in patients with grade 4 adult-type diffuse gliomas mostly occur within residual non-enhancing T2 hyperintensity areas after surgical resection. Unfortunately, it is challenging to distinguish non-enhancing tumors from edema in the non-enhancing T2 hyperintensity areas using conventional MRI alone. Quantitative DCE MRI parameters such as Ktrans and Ve convey permeability information of glioblastomas that cannot be provided by conventional MRI. We used the publicly available nnU-Net to train a deep learning model that incorporated both conventional and DCE MRI to detect the subtle difference in vessel leakiness due to neoangiogenesis between the non-recurrence area and the local recurrence area, which contains a higher proportion of high-grade glioma cells. We found that the addition of Ve doubled the sensitivity while nonsignificantly decreasing the specificity for prediction of local recurrence in glioblastomas, which implies that the combined model may result in fewer missed cases of local recurrence. The deep learning model predictive of local recurrence may enable risk-adapted radiotherapy planning in patients with grade 4 adult-type diffuse gliomas.
Funder
National Research Foundation of Korea (NRF) grant funded by the Korea government
Korea Medical Device Development Fund grant funded by the Korea government
SNUH Research Fund
Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning
Samsung Research Funding & Incubation Center of Samsung Electronics
SNUH GE center grant
Institute for Basic Science
Publisher
Springer Science and Business Media LLC