Abstract
AbstractDeep eutectic solvents aid the formulation of solid pesticide dosage forms for water-insoluble actives. This was demonstrated by encapsulating Amitraz powder in a low-melting matrix based on the eutectic mixture of urea (32 wt%) and 1,3-dimethylurea. Dissolution in water of melt-cast discs, containing 20 wt% active, led to the rapid release of Amitraz in a finely dispersed form. The order of magnitude reduction in particle size, after dissolution, is ascribed to the solubilization of Amitraz in the hot deep eutectic solvent and its subsequent precipitation as a separate phase on crystallization of the matrix.
Funder
Institute of Applied Materials
Publisher
Springer Science and Business Media LLC
Reference9 articles.
1. Collins, R., Paul, Z., Reynolds, D., Short, R. & Wasuwanich, S. Controlled diffusional release of dispersed solute drugs from biodegradable implants of various geometries. Biomed. Sci. Instrum. 33, 137–142 (1997).
2. Schwartz, L., Wolf, D., Markus, A., Wybraniec, S. & Wiesman, Z. Controlled-release systems for the delivery of cyromazine into water surface. J. Agric. Food Chem. 51, 5972–5976. https://doi.org/10.1021/jf034190j (2003).
3. Reddy, L. & Ghosh, B. Fast dissolving drug delivery systems: a review of the literature. Indian J. Pharm. Sci. 64, 331 (2002).
4. Sandell, L. S. & Wysong, R. D. US5714157A (US Patent Office, 1998).
5. Bahrainian, S., Abbaspour, M., Kouchak, M. & Moghadam, P. T. A review on fast dissolving systems: from tablets to nanofibers. Jundishapur J. Nat. Pharm. Prod. https://doi.org/10.5812/jjnpp.34267 (2017).
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