Childhood growth hormone treatment in women with Turner syndrome - benefits and adverse effects

Author:

Irzyniec Tomasz,Jeż Wacław,Lepska Katarzyna,Maciejewska-Paszek IzabelaORCID,Frelich Jakub

Abstract

Abstract Turner syndrome (TS) is characterized by the partial or complete loss of one sex chromosome and results in growth failure, gonadal insufficiency and cardiac anomalies. Treatment with growth hormone (GH) during childhood has indisputable benefits when taking into account the low stature of TS women. Medical records and biochemical findings of 33 TS women treated with GH in childhood (GH+) were compared to those of 124 TS women who did not receive GH (GH−). It seems that the GH-treated group might have had a more severe initial phenotype than the untreated group, as evidenced by higher FSH, more feeding issues in infancy, more lymphedema cases and urinary system malformations. GH+ women were significantly taller and had a better lipid profile and lower prevalence of arterial hypertension than GH− . However, they also had lower thrombocyte counts, a greater prevalence of retrognathism and nail anomalies, especially when the GH treatment was delayed. Long-term GH use was not as effective for growth as GH treatment during the initial period and seemed to have resulted in elevated creatinine levels. GH treatment in childhood has benefits in adulthood; however, adverse effects may occur, especially in individuals with treatment that is delayed or is too long.

Funder

Śląski Uniwersytet Medyczny

Specialist Dental Clinic S.C., Żory

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Cited by 15 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Scoliosis and Kyphosis Prevalence in Turner Syndrome: A Retrospective Review at a Pediatric Tertiary Care Medical Center;Journal of Pediatric Orthopaedics;2023-02-15

2. Challenges of Turner Syndrome Care in Adulthood: A Single Tertiary Center Experience;Clinical and Experimental Obstetrics & Gynecology;2023-01-16

3. Challenges waiting for an adult with DSD;Hormone Research in Paediatrics;2022-12-06

4. Novel insights in Turner syndrome;Current Opinion in Pediatrics;2022-07-05

5. 016 Case report: Turner syndrome;European Journal of Obstetrics & Gynecology and Reproductive Biology;2022-06

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