Author:
Riihimäki Miia,Fegraeus Kim,Nordlund Jessica,Waern Ida,Wernersson Sara,Akula Srinivas,Hellman Lars,Raine Amanda
Abstract
AbstractEquine asthma (EA) is a heterogenous, complex disease, with a significant negative impact on horse welfare and performance. EA and human asthma share fundamental similarities, making EA a useful model for studying the disease. One relevant sample type for investigating chronic lung inflammation is bronchoalveolar lavage fluid (BALF), which provides a snapshot of the immune cells present in the alveolar space. To investigate the immune cell landscape of the respiratory tract in horses with mild-to-moderate equine asthma (mEA) and healthy controls, single-cell RNA sequencing was conducted on equine BALF cells. We characterized the major immune cell populations present in equine BALF, as well as subtypes thereof. Interestingly, the most significantly upregulated gene discovered in cases of mEA was FKBP5, a chaperone protein involved in regulating the activity of the glucocorticoid receptor.
Funder
The Swedish-Norwegian Foundation for Equine Research
Svenska Forskningsrådet Formas
Göran Gustafssons Stiftelse för Naturvetenskaplig och Medicinsk Forskning
Uppsala University
Publisher
Springer Science and Business Media LLC
Cited by
3 articles.
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