Author:
Sakai M.,Tamaki S.,Murata I.,Parajul R. K.,Matsumura A.,Kubo N.,Tashiro M.
Abstract
AbstractBoron neutron capture therapy (BNCT) is a high-dose-intensive radiation therapy that has gained popularity due to advancements in accelerator neutron sources. To determine the dose for BNCT, it is necessary to know the difficult-to-determine boron concentration and neutron fluence. To estimate this dose, we propose a method of measuring the prompt γ-rays (PGs) from the boron neutron capture reaction (BNCR) using a Compton camera. We performed a fundamental experiment to verify basic imaging performance and the ability to discern the PGs from 511 keV annihilation γ-rays. A Si/CdTe Compton camera was used to image the BNCR and showed an energy peak of 478 keV PGs, separate from the annihilation γ-ray peak. The Compton camera could visualize the boron target with low neutron intensity and high boron concentration. This study experimentally confirms the ability of Si/CdTe Compton cameras to image BNCRs.
Funder
Japan Society for the Promotion of Science
Japan Society for the Promotion of Scienc
Publisher
Springer Science and Business Media LLC
Reference67 articles.
1. Locher, G. L. Biological effects and therapeutic possibilities of neutrons. Am. J. Roentgenol. Radium Ther. 36, 13 (1936).
2. Hu, N. et al. Development of a dose distribution shifter to fit inside the collimator of a boron neutron capture therapy irradiation system to treat superficial tumours. Phys. Med. 82, 17–24 (2021).
3. Hiratsuka, J. et al. Long-term outcome of cutaneous melanoma patients treated with boron neutron capture therapy (BNCT). J. Radiat. Res. 61, 945–951 (2020).
4. Kawabata, S. et al. Accelerator-based BNCT for patients with recurrent glioblastoma: A multicenter phase II study. Neurooncol. Adv. 3, vdab067 (2021).
5. Takahara, K., Miyatake, S. I., Azuma, H. & Shiroki, R. Boron neutron capture therapy for urological cancers. Int. J. Urol. 29, 610–616 (2022).