Author:
Meeks Karlijn A. C.,Bentley Amy R.,Doumatey Ayo P.,Adeyemo Adebowale A.,Rotimi Charles N.
Abstract
AbstractAdiponectin has been associated with cardiometabolic traits in observational studies across populations, yet it is unclear if these associations are causal. We performed Mendelian randomization (MR) analysis to assess the relationship between adiponectin and cardiometabolic traits in sub-Saharan Africans. We constructed a polygenic risk score (PRS) for adiponectin levels across 3354 unrelated sub-Saharan Africans. The PRS was used as the instrumental variable in two-stage least-squares MR analysis to assess its association with insulin resistance, HDL, LDL, total cholesterol, triglycerides, blood pressure, Type 2 Diabetes (T2D), and hypertension. The adiponectin PRS was causally related with LDL (β = 0.55, 95%CI 0.07–1.04, P-value = 0.024) but not the other traits. This association was observed in both overweight/obese and normal weight individuals, but only reached statistical significance among overweight/obese individuals (β = 0.55, 95%CI 0.01–1.08, P-value = 0.045). In normal weight individuals, the adiponectin PRS was associated with T2D (OR = 0.13, 95%CI 0.02–0.73, P-value = 0.021), and in men with HDL (β = 1.03, 95%CI 0.14–1.92, P-value = 0.023). The findings of this first MR study in sub-Saharan Africans support a causal relationship of adiponectin with LDL, with T2D in normal weight individuals only, and with HDL in men only. These observations add to the small but growing literature on adiponectin MR studies.
Funder
NIH Office of the Director
National Human Genome Research Institute
National Institutes of Health
Publisher
Springer Science and Business Media LLC
Reference58 articles.
1. World Health Organization. Global status report on noncommunicable diseases 2010 (WHO, 2011).
2. International Diabetes Federation. IDF Diabetes Atlas, Eighth edition. (2017).
3. Adeloye, D. & Basquill, C. Estimating the prevalence and awareness rates of hypertension in Africa: A systematic analysis. PLoS ONE 9, e104300 (2014).
4. FAO, IFAD, UNICEF, WFP and WHO. The State of Food Security and Nutrition in the World 2017. Building resilience for peace and food security (FAO, Rome, Italy, 2017).
5. Chilunga, F. P. et al. Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study. J. Glob. Health 9, 020426. https://doi.org/10.7189/jogh.09.020426 (2019).
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